Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DNAJC31 |
| Protein Type | Chaperone |
| Function | is a member of the DnaJ/Hsp40 family of co-chaperones involved in cellular protein quality control pathways. |
| Primary Expression | various tissues, with expression in the brain suggesting potential roles in neuronal protein homeostasis |
| Molecular Weight | 32 kDa |
| Amino Acids | 298 aa |
| GeneCards | DNAJC31 |
| Human Protein Atlas | DNAJC31 |
| Glycine-rich flexible region | A flexible linker region between the J domain and C-terminal regions that facilitates protein-protein interactions and provides structural flexibility. |
| C-terminal client-binding domain | The C-terminal region is predicted to be involved in recognizing and binding unfolded or misfolded client proteins, containing regions that may form coiled-coil structures. |
| Brain | Expressed in various brain regions including the cerebral cortex, hippocampus, basal ganglia, and cerebellum. Both neuronal and glial cell expression has been detected. |
| Peripheral tissues | Moderate expression in heart, liver, kidney, and skeletal muscle. |
| Cellular localization | Primarily cytosolic localization, consistent with roles in general protein quality control throughout the cell. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC31["DNAJC31"]
neurodegeneration["neurodegeneration"]
DNAJC31 -->|"implicated_in"| neurodegeneration
style DNAJC31 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||