Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DPM1 |
| Full Name | DPM1 (Dolichol-Phosphate Mannosyltransferase Subunit 1) |
| Aliases | Dolichol-Phosphate Mannosyltransferase Subunit 1 |
| Chromosome | 20q13.13 |
| Protein Type | Gene |
| Function | The DPM1 gene encodes the catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex [@dpm]. |
| UniProt ID | O60711 |
| NCBI Gene ID | 8813 |
| Ensembl ID | ENSG00000024219 |
| GeneCards | DPM1 |
| Human Protein Atlas | DPM1 |
| Associated Diseases | Congenital Disorders of Glycosylation |
| Interactions | DPM2, DPM3 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
DPM1(["DPM1"])
Dolichylphosphate_Mannose("Dolichylphosphate Mannose")
DPM2(["DPM2"])
DPM3(["DPM3"])
Congenital_Disorders_of_Glycosylation["Congenital Disorders of Glycosyl..."]
neurodegeneration["neurodegeneration"]
DPM1 -->|"participates in"| Dolichylphosphate_Mannose
DPM1 -->|"interacts with"| DPM2
DPM1 -->|"interacts with"| DPM3
DPM1 -->|"associated with"| Congenital_Disorders_of_Glycosylation
DPM3 -->|"stabilizes"| DPM1
DPM1 -->|"implicated in"| neurodegeneration
style DPM1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Dolichylphosphate Mannose | participates_in | biological_process | 0.90 |
| DPM2 | interacts_with | gene | 0.90 |
| DPM3 | interacts_with | gene | 0.90 |
| Congenital Disorders of Glycosylation | associated_with | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DPM3 | stabilizes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||