Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DUBS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DUBS |
| Related Diseases | ROS, OXIDATIVE_STRESS |
| Related Pathways | UBIQUITIN_SIGNALING, OXIDATIVE_STRESS_RESPONSE, REDOX_REGULATION |
Knowledge base pages for this entity
graph TD
DUBS["DUBS"]
DUBS -->|"regulates"| Ubiquitin_Signaling["Ubiquitin Signaling"]
DUBS -->|"cleaves"| UBIQUITIN["UBIQUITIN"]
DUBS -->|"inhibits"| UBIQUITIN_CONJUGASES["UBIQUITIN CONJUGASES"]
DUBS -->|"modulates"| Protein_Activity["Protein Activity"]
DUBS -->|"regulates"| Protein_Stability["Protein Stability"]
DUBS -->|"regulates"| Protein_Localization["Protein Localization"]
DUBS -->|"regulates"| Ubiquitination["Ubiquitination"]
DUBS -->|"regulates"| UBIQUITIN_SIGNALING["UBIQUITIN_SIGNALING"]
Reactive_Oxygen_Species["Reactive Oxygen Species"] -->|"modulates"| DUBS
Protein_Protein_Interaction["Protein-Protein Interaction"] -->|"regulates"| DUBS
Posttranslational_Modification["Posttranslational Modification"] -->|"regulates"| DUBS
ROS["ROS"] -->|"regulates"| DUBS
OXIDATIVE_STRESS["OXIDATIVE_STRESS"] -->|"regulates"| DUBS
REDOX_REGULATION["REDOX_REGULATION"] -->|"regulates"| DUBS| Target | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN_SIGNALING | regulates | pathway | 0.72 |
| OXIDATIVE_STRESS_RESPONSE | participates_in | pathway | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ROS | regulates | phenotype | 0.64 |
| OXIDATIVE_STRESS | regulates | phenotype | 0.64 |
| REDOX_REGULATION | regulates | pathway | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||