gene

DUSP5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DUSP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for DUSP5 Gene

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🧬 Gene Info

Gene Symbol	DUSP5
Protein Type	Phosphatase
Function	is a nuclear-localized dual-specificity phosphatase that specifically dephosphorylates and inactivates ERK1/2 MAP kinases.
Subcellular Localization	DUSP5 is exclusively nuclear, unlike most other DUSPs which are cytosolic. This nuclear localization is mediated by:
Amino Acids	382 aa
Pathways	MAPK pathway
Ensembl ID	ENSG00000100647
GeneCards	DUSP5
Human Protein Atlas	DUSP5
N-terminal Non-catalytic Domain	Mediates nuclear localization and protein interactions
Phosphatase Domain	Contains the HCX5R motif essential for catalytic activity
Nuclear Localization Signal (NLS)	Directs DUSP5 to the nucleus
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DUSP5 Gene

gene · 936 words

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Pathway Diagram

graph TD
    DUSP5["DUSP5"]
    neurodegeneration["neurodegeneration"]
    DUSP5 -->|"implicated_in"| neurodegeneration
    style DUSP5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning DUSP5 in their description or question text

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