DVL1

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolDVL1
Namedishevelled segment polarity protein 1
Typeprotein-coding
Sourcemygene

Summary

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which mi

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