gene

DYNC1H1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNC1H1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

1Analyses

1Outgoing

0Incoming

0Experiments

2Debates

Summary

Gene profile: DYNC1H1

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🧬 Gene Info

Gene Symbol	DYNC1H1
Full Name	Dynein Cytoplasmic 1 Heavy Chain 1
Chromosome	14q32.31
Function	Dynein transports diverse cargo including mitochondria, endosomes, lysosomes, signaling endosomes, and mRNA granules from the distal axon back toward the cell body (retrograde transport).
Primary Expression	Motor neurons, Cerebral cortex, Widespread
Molecular Weight	532 kDa
UniProt ID	Q14204
NCBI Gene ID	1778
Ensembl ID	ENSG00000197958
OMIM	600112
GeneCards	DYNC1H1
Human Protein Atlas	DYNC1H1
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYNC1H1 — AlphaFold Q14204 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYNC1H1 — Dynein Cytoplasmic 1 Heavy Chain 1

gene · 1188 words

→

DYNC1H1 Protein

protein · 765 words

→

Pathway Diagram

graph TD
    DYNC1H1["DYNC1H1"]
    neurodegeneration["neurodegeneration"]
    DYNC1H1 -->|"implicated_in"| neurodegeneration
    style DYNC1H1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
anterograde tau transport	regulates	mechanism	0.50

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning DYNC1H1 in their description or question text

No additional research found