Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Disease Models: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Gene Editing | associated_with | mechanism | 0.85 |
| HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED NEURONS | used_for | cell_type | 0.80 |
| HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED ASTROCYTES | used_for | cell_type | 0.80 |
| HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED MICROGLIA | used_for | cell_type | 0.80 |
| HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED ENDOTHELIAL CELLS | used_for | cell_type | 0.80 |
| HUMAN INDUCED PLURIPOTENT STEM CELL (IPSC)-DERIVED PERICYTES | used_for | cell_type | 0.80 |
| iPSC-Derived Neurons | involved_in | cell_type | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A | 0.790 | neurodegeneration | epigenetic reprogramming aging neurons |
| Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-Hig | 0.680 | neurodegeneration | - |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Disease Models in their description or question text
No additional research found