gene

EARS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

Summary

Comprehensive analysis of EARS2 gene function in mitochondrial translation, leucine encephalopathy, and implications for neurodegenerative diseases including Alzheimer's and Parkinson's

View on Wiki →

🧬 Gene Info

Gene Symbol	EARS2
Full Name	Mitochondrial Glutamyl-tRNA Synthetase
Protein Type	Synthetase
Function	is an essential mitochondrial aminoacyl-tRNA synthetase (mtARS) that catalyzes the charging of glutamate to its cognate mitochondrial tRNA.
Amino Acids	200 aa
Ensembl ID	ENSG00000120784
GeneCards	EARS2
Human Protein Atlas	EARS2
Aminoacylation domain	The active site that catalyzes glutamate activation and tRNA charging
ATP-binding pocket	Conserved KMSKS loop that binds ATP
acceptor stem binding region	Recognizes the 3' end of tRNA
Helical domain	Mediates protein-protein interactions
Dimerization interface	EARS2 functions as a dimer
tRNA recognition elements	Additional binding surfaces for tRNA specificity
Rossmann fold	Central β-sheet with α-helices in catalytic domain
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EARS2["EARS2"]
    neurodegeneration["neurodegeneration"]
    EARS2 -->|"implicated_in"| neurodegeneration
    style EARS2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found