Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF2B5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EIF2B5 (Eukaryotic Translation Initiation Factor 2B Subunit Epsilon): The catalytic subunit of eIF2B, the guanine nucleotide exchange factor for eIF2. Critical for translational initiation and the integrated stress response. Mutations cause Vanishing White Matter Disease.
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| Gene Symbol | EIF2B5 |
| Full Name | Eukaryotic Translation Initiation Factor 2B Subunit Epsilon |
| Chromosome | 3q27.2 |
| Primary Expression | olodendrocytes, astrocytes, and neurons, with particularly high level |
| Subcellular Localization | Cytoplasmic, associated with the translational machinery |
| Molecular Weight | 82 kDa |
| Amino Acids | 721 aa |
| Exons | 15 |
| UniProt ID | [P05198](https://www.uniprot.org/uniprot/P05198) |
| Ensembl ID | ENSG00000145191 |
| OMIM | 603951 |
| GeneCards | EIF2B5 |
| Human Protein Atlas | EIF2B5 |
| Core complex | 2 copies each of subunits α, β, γ (a/b/g heterotrimer) |
| Regulatory subcomplex | 1 copy each of subunits δ and ε |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EIF2B5["EIF2B5"]
neurodegeneration["neurodegeneration"]
EIF2B5 -->|"implicated_in"| neurodegeneration
style EIF2B5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EIF2B5 in their description or question text
No additional research found