gene

ERCC9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERCC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ERCC9 (also known as FANCN) encodes a DNA repair protein essential for the Fanconi anemia pathway and transcription-coupled nucleotide excision repair. ERCC9 dysfunction leads to neurodegeneration, Cockayne syndrome, and increased cancer risk.

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🧬 Gene Info

Gene Symbol	ERCC Excision Repair 9, Complementing
Aliases	also known as FANCN
Chromosome	9q33.2
Protein Type	DNA Repair Protein, Fanconi Anemia Pathway
Function	encodes a DNA repair protein essential for the Fanconi anemia pathway and transcription-coupled nucleotide excision repair (TC-NER)[@bogliolo2007].
Amino Acids	462 aa
UniProt ID	Q8IYD1
NCBI Gene ID	2075
Ensembl ID	ENSG00000135821
OMIM	614721
Brain	Neurons in cortex, hippocampus, and basal ganglia
Bone marrow	Hematopoietic stem and progenitor cells
Liver	Hepatocytes
Kidney	Tubular epithelial cells
Testis	Spermatogenic cells
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ERCC9 — AlphaFold Q8IYD1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ERCC9 (FANCN) - DNA Repair and Neurodegeneration

gene · 1507 words

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Pathway Diagram

graph TD
    ERCC9["ERCC9"]
    neurodegeneration["neurodegeneration"]
    ERCC9 -->|"implicated_in"| neurodegeneration
    style ERCC9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ERCC9 in their description or question text

No additional research found