Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERLIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ERLIN2 |
| Full Name | ER Lipid Raft Associated 2 |
| Chromosome | 8p11.2 |
| Function | ERLIN2 encodes a member of the prohibitin domain family and is part of the ERLIN1/ERLIN2 complex in the ER membrane. |
| Subcellular Localization | the endoplasmic reticulum (ER) that plays critical roles in ER-associated degradation (ERAD) and cholesterol homeostasis |
| Molecular Weight | 37.8 kDa |
| UniProt ID | O94905 |
| NCBI Gene ID | 11160 |
| Ensembl ID | ENSG00000130771 |
| OMIM | 611605 |
| GeneCards | ERLIN2 |
| Human Protein Atlas | ERLIN2 |
| Protein quality control | Identifying and targeting misfolded proteins for degradation |
| Ubiquitin-proteasome pathway | Working with the ubiquitin-proteasome system to clear damaged proteins |
| Cholesterol sensing | Responding to cellular cholesterol levels |
| Associated Diseases | Hereditary Spastic Paraplegia, Primary Lateral Sclerosis |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ERLIN2["ERLIN2"]
TREM2["TREM2"]
ApoE["ApoE"]
neurodegeneration["neurodegeneration"]
ERLIN2 -->|"associated with"| TREM2
ERLIN2 -->|"upregulates"| ApoE
ERLIN2 -->|"implicated in"| neurodegeneration
style ERLIN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style TREM2 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style ApoE fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ERLIN2 in their description or question text
No additional research found