gene

ESCO2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ESCO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for ESCO2 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2

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🧬 Gene Info

Gene Symbol	ESCO2
Full Name	Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2
Aliases	Page for ESCO2
Protein Type	Transferase
Function	is an S-phase specific lysine acetyltransferase that acetylates the SMC3 subunit of the cohesin complex, a modification essential for establishing sister chromatid cohesion during DNA replication.
Ensembl ID	ENSG00000174607
GeneCards	ESCO2
Human Protein Atlas	ESCO2
Establishes cohesion	Creates stable sister chromatid linkages during S phase
Prevents premature separation	Protects cohesin from WAPL-mediated release
Ensures faithful segregation	Enables accurate chromosome distribution at anaphase[@unal2008]
Prenatal growth deficiency	Severe growth restriction beginning in utero
Limb reductions	Tetraphocomelia (severe limb shortening) or milder limb defects
Craniofacial abnormalities	Cleft lip/palate, hypertelorism, micrognathia
Chromosomal instability	Premature centromere separation (PCS)
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESCO2 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2

gene · 711 words

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Pathway Diagram

graph TD
    ESCO2["ESCO2"]
    neurodegeneration["neurodegeneration"]
    ESCO2 -->|"implicated_in"| neurodegeneration
    style ESCO2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ESCO2 in their description or question text

No additional research found