FADD

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolFADD
NameFas associated via death domain
Typeprotein-coding
Sourcemygene

Summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows

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