gene

FANCL

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about FANCL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for FANCL Gene

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🧬 Gene Info

Gene Symbol	FANCL
Full Name	Fanconi Anemia Group L
Chromosome	2p16.3
Function	FANCL is the catalytic E3 ubiquitin ligase subunit of the Fanconi anemia (FA) core complex.
Primary Expression	most tissues:
Molecular Weight	43 kDa
Amino Acids	380 aa
UniProt ID	Q9NZB7
Ensembl ID	ENSG00000115652
OMIM	608111
GeneCards	FANCL
Human Protein Atlas	FANCL
E3 Ubiquitin Ligase	Catalyzes FANCD2 monoubiquitination
FA Core Complex	Catalytic subunit of the FA core E3 ligase
DNA Damage Response	Activates FA pathway in response to DNA damage
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FANCL — AlphaFold Q9NZB7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FANCL Gene

gene · 537 words

→

FANCL Protein

protein · 1002 words

→

Pathway Diagram

graph TD
    FANCL["FANCL"]
    neurodegeneration["neurodegeneration"]
    FANCL -->|"implicated_in"| neurodegeneration
    style FANCL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning FANCL in their description or question text

No additional research found