Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FBXO31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | FBXO31 |
| Full Name | F-box Protein 31 |
| Chromosome | 16q24.2 |
| Protein Family | F-box family, SCF ubiquitin ligase complex |
| Function | encodes a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex, a critical component of the ubiquitin-proteasome system (UPS). |
| Amino Acids | 483 aa |
| UniProt ID | Q8IFY6 |
| NCBI Gene ID | 79791 |
| Ensembl ID | ENSG00000103265 |
| OMIM | 609102 |
| GeneCards | FBXO31 |
| Human Protein Atlas | FBXO31 |
| F-box domain | The defining feature of F-box proteins, approximately 50 amino acids, mediates binding to Skp1 |
| Substrate-binding region | Variable region determining substrate specificity |
| Phosphorylation recognition motif | Recognizes phosphorylated serine/threonine residues on substrates |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FBXO31["FBXO31"]
neurodegeneration["neurodegeneration"]
FBXO31 -->|"implicated_in"| neurodegeneration
style FBXO31 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FBXO31 in their description or question text
No additional research found