gene

FCGR1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FCGR1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for FCGR1A gene

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🧬 Gene Info

Gene Symbol	FCGR1A
Full Name	Fc Gamma Receptor IA
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	45 kDa
Pathways	PI3K, MAPK, NF-κB, MAPK pathway
Ensembl ID	ENSG00000110324
GeneCards	FCGR1A
Human Protein Atlas	FCGR1A
Syk phosphorylation	Activation of PLCγ, Ca²⁺ mobilization
PI3K/Akt	Cell survival, phagocytosis
MAPK/ERK	Gene transcription, cytokine production
[NF-κB](/entities/nf-kb)	Pro-inflammatory gene expression
Phagocytosis	Opsonization of IgG-coated targets
ADCC	NK cell activation via Fc binding
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FCGR1A["FCGR1A"]
    neurodegeneration["neurodegeneration"]
    FCGR1A -->|"implicated_in"| neurodegeneration
    style FCGR1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FCGR1A

Understanding Entity Pages

Summary

Wiki Pages (5)

FCGR1A - Fc Gamma Receptor IA

Microglia Activation Mechanism

FCGR1A Protein - Fc Gamma Receptor IA

Proteins