protein

FEN1_PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about FEN1_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

FEN1 Protein

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🔬 Protein Info

Gene Symbol	FEN1-PROTEIN
Aliases	FEN1_PROTEIN
Protein Type	Enzyme
Function	is a key DNA repair enzyme essential for DNA replication and repair processes[@liu2000].
Subcellular Localization	Nucleus
Molecular Weight	~43 kDa
UniProt ID	P39748
GeneCards	FEN1-PROTEIN
Human Protein Atlas	FEN1-PROTEIN
Flap endonuclease activity	Cleaves flap structures that form during DNA replication
5' exonuclease activity	Removes RNA-DNA primers during Okazaki fragment processing
3' exonuclease activity	Provides proofreading capability
N-terminal domain	Contains the active site for nuclease activity
Intermediate domain	Involved in substrate binding
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FEN1_PROTEIN — AlphaFold P39748 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FEN1 Protein

protein · 687 words

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Pathway Diagram

graph TD
    FEN1_PROTEIN["FEN1_PROTEIN"]
    neurodegeneration["neurodegeneration"]
    FEN1_PROTEIN -->|"implicated_in"| neurodegeneration
    style FEN1_PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning FEN1_PROTEIN in their description or question text

No additional research found