Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive gene profile for Fibroblast Growth Factor 6 (FGF6), a member of the fibroblast growth factor family with roles in muscle regeneration, neurogenesis, and cellular survival signaling relevant to neurodegenerative diseases.
| Gene Symbol | FGF6 |
| Full Name | Fibroblast Growth Factor 6 |
| Chromosome | 12p13.32 |
| Function | is a member of the fibroblast growth factor family of signaling proteins that play critical roles in development, tissue repair, and cellular homeostasis. |
| Molecular Weight | 24 kDa |
| Amino Acids | 208 aa |
| Exons | 5 |
| UniProt ID | [P38467](https://www.uniprot.org/uniprot/P38467) |
| Ensembl ID | ENSG00000140391 |
| GeneCards | FGF6 |
| Human Protein Atlas | FGF6 |
| N-terminal signal peptide | Directs secretion via the secretory pathway |
| Core conserved domain | The characteristic FGF homology domain (~120-150 amino acids) |
| Heparin-binding domain | Critical for interaction with heparan sulfate proteoglycans and FGF receptors |
| Receptor binding sites | Sites for interaction with FGF receptor tyrosine kinases |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FGF6["FGF6"]
neurodegeneration["neurodegeneration"]
FGF6 -->|"implicated_in"| neurodegeneration
style FGF6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||