gene

FRDA1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about FRDA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

FRDA1 gene encoding frataxin - a mitochondrial protein essential for iron-sulfur cluster biogenesis, linked to Friedreich ataxia and neurodegeneration

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🧬 Gene Info

Gene Symbol	FRDA1
Full Name	FXN (Frataxin)
Aliases	FRDA1 gene encoding frataxin
Chromosome	9q21.11
Amino Acids	210 aa
UniProt ID	[Q16595](https://www.uniprot.org/uniprotkb/Q16595/entry)
GeneCards	FRDA1
Human Protein Atlas	FRDA1
Iron import regulation	Controls mitochondrial iron uptake through MIYAML
Iron storage coordination	Works with mitochondrial ferritin (FTMT)
Prevents iron overload	Avoids toxic Fenton chemistry
Protects against ferroptosis	Mitochondrial iron-mediated cell death
Heart	Highest expression - explains cardiac involvement
Liver	High metabolic demand
Kidney	Energy-intensive transport
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

FRDA1 Gene - Frataxin (FXN)

gene · 1608 words

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Pathway Diagram

graph TD
    FRDA1["FRDA1"]
    neurodegeneration["neurodegeneration"]
    FRDA1 -->|"implicated_in"| neurodegeneration
    style FRDA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning FRDA1 in their description or question text

No additional research found