protein

FZD6PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FZD6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

FZD6 (Frizzled-6) is a seven-transmembrane receptor that belongs to the Frizzled family of Wnt receptors. It activates both canonical and non-canonical Wnt signaling pathways, particularly the planar cell polarity (PCP) pathway.

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🔬 Protein Info

Gene Symbol	FZD6PROTEIN
Protein Type	Receptor
Function	is a seven-transmembrane receptor that belongs to the Frizzled family of Wnt receptors.
Subcellular Localization	** \| Plasma membrane, endosomes \|
Molecular Weight	71 kDa
GeneCards	FZD6PROTEIN
Human Protein Atlas	FZD6PROTEIN
Convergent extension	Controls cell movement during embryogenesis
Neural tube closure	Regulates the bending and closure of the neural tube
Hair follicle orientation	Determines hair follicle planar polarity
Inner ear hair cell orientation	Critical for stereocilia organization
Amyloid-beta production	FZD6 regulates amyloid precursor protein (APP) processing and amyloid-beta generation
Memory deficits	FZD6 deficiency exacerbates memory impairment in mouse models
Synaptic dysfunction	Alters Wnt signaling at synapses affecting synaptic plasticity
Neuronal survival	Modulates neuronal survival pathways
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

fzd6-protein

protein · 1047 words

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Pathway Diagram

graph TD
    FZD6PROTEIN["FZD6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    FZD6PROTEIN -->|"implicated_in"| neurodegeneration
    style FZD6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning FZD6PROTEIN in their description or question text

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