gene

GABBR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABBR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for GABBR2 — Gamma-Aminobutyric Acid Type B Receptor Subunit 2

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🧬 Gene Info

Gene Symbol	GABBR2
Full Name	Gamma-Aminobutyric Acid Type B Receptor Subunit 2
Chromosome	9q22.33
Function	encodes the GABA-B2 subunit of the metabotropic GABA receptor
Primary Expression	Cerebral cortex, Hippocampus, Thalamus, Cerebellum, Brainstem
Amino Acids	941 aa
UniProt ID	O75899
NCBI Gene ID	9568
Ensembl ID	ENSG00000136928
OMIM	607340
GeneCards	GABBR2
Human Protein Atlas	GABBR2
G-protein coupling	The heptahelical domain of GABBR2 activates Gi/o heterotrimeric G-proteins upon receptor activation
Surface trafficking	Masks the ER retention signal (RSRR motif) on GABBR1, enabling the heterodimer to exit the ER
Allosteric modulation	The venus flytrap domain of GABBR2 does not bind GABA but allosterically enhances agonist affinity at GABBR1
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABBR2 — AlphaFold O75899 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABBR2 — Gamma-Aminobutyric Acid Type B Receptor Subunit 2

gene · 761 words

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Pathway Diagram

flowchart TD
    N0["GABBR2"]
    N1["SLC39A8"]
    N1 -->|"regulates"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
SLC39A8	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity