Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRQ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRQ encodes the theta (θ) subunit of the GABA-A receptor, critically involved in inhibitory neurotransmission, thalamocortical oscillations, and implicated in epilepsy, sleep disorders, and neurodegenerative diseases.
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| Gene Symbol | GABRQ |
| Full Name | GABA-A Receptor Theta Subunit |
| Chromosome | Xq12 |
| Protein Family | Cys-loop ligand-gated ion channel superfamily |
| Protein Type | Receptor |
| Function | encodes a 454-amino acid protein that assembles with other GABA-A receptor subunits to form functional ion channels. |
| Molecular Weight | 51 kDa |
| Amino Acids | 454 aa |
| Exons | 9 |
| UniProt ID | A8MXD4 |
| NCBI Gene ID | 2776 |
| Ensembl ID | ENSG00000145495 |
| OMIM | 300426 |
| GeneCards | GABRQ |
| Human Protein Atlas | GABRQ |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GABRQ["GABRQ"]
neurodegeneration["neurodegeneration"]
GABRQ -->|"implicated_in"| neurodegeneration
style GABRQ fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GABRQ in their description or question text
No additional research found