gene

GABRR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

GABRR3 (GABA-A Receptor Rho3 Subunit) - GABA-C/ρ receptor subunit involved in inhibitory neurotransmission, retinal signaling, synaptic inhibition, and implicated in epilepsy, neurodevelopmental disorders, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	GABRR3
Aliases	GABA-A Receptor Rho3 Subunit
Chromosome	15q12
Protein Type	Receptor
Function	encodes a protein that forms ionotropic GABA receptors (historically called GABA-C receptors, now properly classified as GABA-A ρ receptors).
Subcellular Localization	## Molecular Functions
Molecular Weight	52 kDa
Amino Acids	458 aa
UniProt ID	P28476
NCBI Gene ID	505
Ensembl ID	ENSG00000186283
OMIM	603430
GeneCards	GABRR3
Human Protein Atlas	GABRR3
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABRR3 — AlphaFold P28476 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABRR3 Gene

gene · 1984 words

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Pathway Diagram

flowchart TD
    N0["GABRR3"]
    N1["GABAARECEPTORTHETAPROTEIN"]
    N0 -->|"binds"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
GABAARECEPTORTHETAPROTEIN	binds	receptor	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABRR3 in their description or question text

No additional research found