gene

GATAD2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GATAD2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Debates

Summary

GATAD2A is a transcriptional repressor and component of the NuRD (Nucleosome Remodeling Deacetylase) complex. It is implicated in Parkinson's disease risk through GWAS and plays critical roles in chromatin remodeling, gene regulation, and neuronal survival.

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🧬 Gene Info

Gene Symbol	GATAD2A
Full Name	GATA Zinc Finger Domain Containing 2A
Aliases	Nucleosome Remodeling Deacetylase
Chromosome	19p13.2
Function	GATAD2A plays critical roles in gene regulation through its involvement in the NuRD complex:
Primary Expression	human tissues: - Brain: High expression in cortex, hippocampus, [striatum](/brain-
Amino Acids	593 aa
UniProt ID	Q9ULJ8
NCBI Gene ID	54898
Ensembl ID	ENSG00000176165
OMIM	607336
GeneCards	GATAD2A
Human Protein Atlas	GATAD2A
Histone deacetylation	HDAC1/2 remove acetyl groups, creating transcriptionally repressive chromatin
Nucleosome remodeling	CHD4 repositioning makes DNA less accessible to transcription factors
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GATAD2A — AlphaFold Q9ULJ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GATAD2A — GATA Zinc Finger Domain Containing 2A

gene · 658 words

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Pathway Diagram

graph TD
    GATAD2A["GATAD2A"]
    neurodegeneration["neurodegeneration"]
    GATAD2A -->|"implicated in"| neurodegeneration
    Parkinson_S_Disease{"Parkinson'S Disease"}
    GATAD2A -->|"implicated in"| Parkinson_S_Disease
    Neuronal_Survival(["Neuronal Survival"])
    GATAD2A -->|"promotes"| Neuronal_Survival
    Transcription(["Transcription"])
    GATAD2A -->|"regulates"| Transcription
    style GATAD2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Transcription fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Neuronal_Survival fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GATAD2A in their description or question text

No additional research found