gene

GCHFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCHFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive review of GCHFR gene, a negative regulator of tetrahydrobiopterin biosynthesis with roles in dopamine production, neurological function, and disease

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🧬 Gene Info

Gene Symbol	GCHFR
Full Name	GTP Cyclohydrolase I Feedback Regulator
Chromosome	9q34.3
Protein Type	Enzyme
Function	is an essential cofactor for several critical enzymatic reactions, including phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase—enzymes required for neurotransmitter synthe...
Primary Expression	Brain (substantia nigra, striatum), liver, adrenal gland
Molecular Weight	9.5 kDa
Amino Acids	83 aa
UniProt ID	Q8WY44
Ensembl ID	ENSG00000108468
GeneCards	GCHFR
Human Protein Atlas	GCHFR
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GCHFR — AlphaFold Q8WY44 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GCHFR — GTP Cyclohydrolase I Feedback Regulator

gene · 1391 words

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Pathway Diagram

graph TD
    GCHFR["GCHFR"]
    neurodegeneration["neurodegeneration"]
    GCHFR -->|"implicated_in"| neurodegeneration
    style GCHFR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GCHFR in their description or question text

No additional research found