gene

GEMIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEMIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GEMIN2 gene in ALS and SMA - SMN complex

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🧬 Gene Info

Gene Symbol	Gem Nuclear Organelle Associated Protein 2
Aliases	GEMIN2 gene in ALS and SMA
Chromosome	14q13.2
Function	is a critical component of the SMN (Survival of Motor Neuron) complex that is essential for spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis.
Gene Type	Protein coding
UniProt ID	O94876
NCBI Gene ID	25956
Ensembl ID	ENSG00000145901
OMIM	609721
SMN	The catalytic core, with an SMA domain and Tudor domain
GEMIN2 (SIP1)	RNA-binding adaptor that recruits snRNA
GEMIN1	Scaffold protein organizing the complex
GEMIN3 (DDX20)	RNA helicase
GEMIN4	Component with RNA-binding capacity
GEMIN5	Component recognizing snRNA sequences
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GEMIN2 — AlphaFold O94876 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GEMIN2 Gene

gene · 2159 words

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Pathway Diagram

graph TD
    GEMIN2["GEMIN2"]
    neurodegeneration["neurodegeneration"]
    GEMIN2 -->|"implicated_in"| neurodegeneration
    style GEMIN2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning GEMIN2 in their description or question text

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