gene

GEMIN3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GEMIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GEMIN3/DDX20 gene in ALS - RNA helicase

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🧬 Gene Info

Gene Symbol	GEMIN3
Aliases	GEMIN3/DDX20 gene in ALS
Function	GEMIN3 (Gem Nuclear Organelle Associated Protein 3), also known as DDX20 (DEAD-Box Helicase 20), is a member of the DEAD-box RNA helicase family and a core component of the SMN complex.
Ensembl ID	ENSG00000089356
GeneCards	GEMIN3
Human Protein Atlas	GEMIN3
RNA Helicase Activity	Unwinds RNA duplexes in an ATP-dependent manner
ATPase Activity	Uses ATP hydrolysis to power conformational changes
RNA Binding	Binds various RNA species including snRNA, miRNA, and mRNA
Spliceosomal snRNP Assembly	Facilitates proper assembly of the SMN complex with snRNA
miRNA Biogenesis	Involved in microRNA processing through interaction with the microprocessor complex
Transcriptional Regulation	Modulates gene expression through interactions with transcription factors
DEAD box motif	Characteristic sequence of DEAD-box helicases
RNA binding	Binds single-stranded RNA
Unwinding activity	Separates RNA duplexes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GEMIN3 Gene

gene · 1098 words

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Pathway Diagram

graph TD
    GEMIN3["GEMIN3"]
    neurodegeneration["neurodegeneration"]
    GEMIN3 -->|"implicated_in"| neurodegeneration
    style GEMIN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Related Research

Hypotheses and analyses mentioning GEMIN3 in their description or question text

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