Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GFRA3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gfrα3 Protein Gdnf Family Receptor Alpha 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Gene Symbol | GFRA3PROTEIN |
| Chromosome | 4p15.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | ~45-50 kDa (pre-pro form) |
| Amino Acids | 465 amino acids |
| UniProt ID | Q9Y5R5 |
| NCBI Gene ID | 64054 |
| Ensembl ID | ENSG00000146070 |
| GeneCards | GFRA3PROTEIN |
| Human Protein Atlas | GFRA3PROTEIN |
| Signal peptide (1-21 aa) | N-terminal signal sequence for cotranslational insertion into the endoplasmic reticulum |
| N-terminal domain | Contains the ligand-binding interface |
| Three cysteine-rich domains (CRDs) | Each CRD contains conserved cysteine residues forming disulfide bonds that create the structural framework for artemin binding |
| GPI anchor signal sequence (C-terminus) | Directs post-translational attachment of the GPI moiety, anchoring the protein to the outer leaflet of the plasma membrane |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GFRA3PROTEIN["GFRA3PROTEIN"]
neurodegeneration["neurodegeneration"]
GFRA3PROTEIN -->|"implicated_in"| neurodegeneration
style GFRA3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GFRA3PROTEIN in their description or question text
No additional research found