gene

GFRA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFRA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for GFRA4 - GDNF Family Receptor Alpha 4

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🧬 Gene Info

Gene Symbol	GFRA4
Full Name	GDNF Family Receptor Alpha 4
Aliases	Page for GFRA4
Chromosome	20p13
Protein Type	Receptor
Function	is a GPI-anchored cell surface receptor that serves as the primary receptor for persephin (PSPN).
Molecular Weight	37 kDa
Pathways	PI3K, MAPK
UniProt ID	Q9H3R5
NCBI Gene ID	391720
GeneCards	GFRA4
Human Protein Atlas	GFRA4
N-terminal signal peptide	Directs GPI anchor attachment
Cysteine-rich domain (CRD)	Stabilizes ligand-receptor complex
GPI anchor signal sequence	C-terminal signal for membrane attachment
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GFRA4 — AlphaFold Q9H3R5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GFRA4 - GDNF Family Receptor Alpha 4

gene · 1769 words

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Pathway Diagram

graph TD
    GFRA4["GFRA4"]
    neurodegeneration["neurodegeneration"]
    GFRA4 -->|"implicated_in"| neurodegeneration
    style GFRA4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFRA4 in their description or question text

No additional research found