Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GFRA4PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gfrα4 Protein Gdnf Family Receptor Alpha 4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
No AI portrait yet
| Gene Symbol | GFRA4 |
| Full Name | GDNF Family Receptor Alpha 4 |
| Aliases | Page for GFRA4 |
| Chromosome | 20p13 |
| Protein Family | GDNF family receptor alpha |
| Protein Type | Receptor |
| Function | is a GPI-anchored cell surface receptor that serves as the primary receptor for persephin (PSPN). |
| Molecular Weight | Approximately 42-45 kDa |
| Pathways | PI3K, MAPK |
| UniProt ID | Q9H3R5 |
| NCBI Gene ID | 391720 |
| GeneCards | GFRA4 |
| Human Protein Atlas | GFRA4 |
| Amino Acid Length | 377-401 amino acids (species-dependent) |
| UniProt Accession | Q9H3R5 (human) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GFRA4PROTEIN["GFRA4PROTEIN"]
neurodegeneration["neurodegeneration"]
GFRA4PROTEIN -->|"implicated_in"| neurodegeneration
style GFRA4PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GFRA4PROTEIN in their description or question text
No additional research found