Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GJA1 (Cx43) - context-dependent: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| cell biology | promoted: Context-Dependent Cx43 Modulation Based on Disease Stage | disease | 0.58 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Context-Dependent Cx43 Modulation Based on Disease Stage | 0.724 | cell-biology | What is the relative contribution of con |
Scientific analyses that reference this entity
cell biology | 2026-04-12 | 2 hypotheses Top: 0.724
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| H₂O₂-induced oxidative stress in isolated chondrocytes | exploratory | Temporomandibular joint osteoa | 0.900 | 0.00 | Isolated chondrocytes | proposed | N/A |
| Unilateral anterior crossbite (UAC) model of TMJOA in rats | validation | Temporomandibular joint osteoa | 0.900 | 0.00 | Rats with unilateral anterior | proposed | N/A |
| Gap26 inhibitor treatment in cellular TMJOA model | exploratory | Temporomandibular joint osteoa | 0.900 | 0.00 | H₂O₂-treated chondrocytes with | proposed | N/A |
| Gap26 treatment in UAC rat model of TMJOA | validation | Temporomandibular joint osteoa | 0.800 | 0.00 | UAC rats treated with Gap26 in | proposed | N/A |
| Cx43-β-catenin protein-protein interaction analysis | exploratory | Temporomandibular joint osteoa | 0.800 | 0.00 | Cell-based protein interaction | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning GJA1 (Cx43) - context-dependent in their description or question text
No additional research found