gene

GLRA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLRA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GLRA2 encodes the alpha-2 subunit of the glycine receptor, critical for inhibitory neurotransmission in the spinal cord and brainstem. Mutations cause hyperekplexia and are implicated in epilepsy and neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	Glycine Receptor Alpha 2
Chromosome	Xp22.2
Molecular Weight	52 kDa
Amino Acids	462 aa
UniProt ID	P23416
NCBI Gene ID	2745
Ensembl ID	ENSG00000145888
OMIM	305990
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GLRA2 — AlphaFold P23416 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GLRA2

gene · 1582 words

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Pathway Diagram

graph TD
    GLRA2["GLRA2"]
    neurodegeneration["neurodegeneration"]
    GLRA2 -->|"implicated_in"| neurodegeneration
    style GLRA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLRA2 in their description or question text

No additional research found