Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNA15PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The GNA15 protein is a G protein alpha subunit characterized by canonical G protein domain architecture[@oldham2008].
No AI portrait yet
| Gene Symbol | GNA15PROTEIN |
| Full Name | GNA15 (G Alpha 15) |
| Protein Type | Protein |
| Function | is a protein encoded by the GNA15 gene that functions as a G protein alpha subunit primarily expressed in hematopoietic cells. |
| Primary Expression | hematopoietic cells |
| Subcellular Localization | ** Plasma membrane **Protein Family:** G alpha q/11 family ## Structure The |
| UniProt ID | Search UniProt |
| GeneCards | GNA15PROTEIN |
| Human Protein Atlas | GNA15PROTEIN |
| GTP-binding domain | Responsible for nucleotide binding and hydrolysis |
| Switch regions (I, II, III) | Undergo conformational changes upon GTP binding and hydrolysis |
| Alpha-helical domain | Involved in effector interaction |
| N-terminal helix | Required for membrane association and receptor coupling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNA15PROTEIN["GNA15PROTEIN"]
neurodegeneration["neurodegeneration"]
GNA15PROTEIN -->|"implicated_in"| neurodegeneration
style GNA15PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GNA15PROTEIN in their description or question text
No additional research found