Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNAT1 encodes the alpha subunit of transducin (Gt1), a heterotrimeric G protein essential for phototransduction in rod photoreceptor cells. GNAT1 mutations cause autosomal dominant and recessive retinitis pigmentosa, congenital stationary night blindness, and other retinal disorders
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| Gene Symbol | GNAT1 |
| Full Name | G Protein Subunit Alpha Transducin 1 |
| Aliases | G Protein Alpha Transducin 1 |
| Chromosome | 3p21.31 |
| Protein Family | G protein alpha subunits (Gα_t family) |
| Function | is a critical component of the rod phototransduction cascade |
| Molecular Weight | 40.0 kDa |
| Amino Acids | 350 aa |
| Exons | 12 |
| UniProt ID | P11488 |
| NCBI Gene ID | 2774 |
| Ensembl ID | ENSG00000114349 |
| OMIM | 139312 |
| GeneCards | GNAT1 |
| Human Protein Atlas | GNAT1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GNAT1["GNAT1"]
neurodegeneration["neurodegeneration"]
GNAT1 -->|"implicated in"| neurodegeneration
Retinitis_Pigmentosa{"Retinitis Pigmentosa"}
GNAT1 -->|"implicated in"| Retinitis_Pigmentosa
STAT["STAT"]
GNAT1 ---|"interacts"| STAT
style GNAT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Retinitis_Pigmentosa fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GNAT1 in their description or question text
No additional research found