gene

GNB3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GNB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

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0Experiments

0Debates

Summary

GNB3 encodes the beta3 subunit of heterotrimeric G proteins, a critical component of GPCR signal transduction. The GNB3 C825T polymorphism is associated with enhanced G-protein coupling and linked to hypertension, depression, obesity, and Parkinson's disease

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🧬 Gene Info

Gene Symbol	GNB3
Full Name	G Protein Subunit Beta 3
Chromosome	12p13.31
Protein Family	G protein beta subunits
Function	is a central component of GPCR signal transduction
Molecular Weight	55 kDa
Amino Acids	340 aa
Exons	11
UniProt ID	P16520
NCBI Gene ID	2784
Ensembl ID	ENSG00000111664
OMIM	139310
GeneCards	GNB3
Human Protein Atlas	GNB3
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GNB3 — AlphaFold P16520 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GNB3 Gene

gene · 1485 words

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Pathway Diagram

graph TD
    GNB3["GNB3"]
    neurodegeneration["neurodegeneration"]
    GNB3 -->|"implicated in"| neurodegeneration
    Depression{"Depression"}
    GNB3 -->|"implicated in"| Depression
    Parkinson_S_Disease{"Parkinson'S Disease"}
    GNB3 -->|"implicated in"| Parkinson_S_Disease
    Signal_Transduction(["Signal Transduction"])
    GNB3 -->|"regulates"| Signal_Transduction
    style GNB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Depression fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Signal_Transduction fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNB3 in their description or question text

No additional research found