gene

GOLGA8FTLDFET

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GOLGA8FTLDFET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	GOLGA8FTLDFET
Function	is a spectrum of neurodegenerative diseases characterized by abnormal protein aggregates containing FET family proteins (FUS), TAF15, and EWS.
Primary Expression	neuronal tissues and is localized to the Golgi apparatus, where it plays a role in protein sorting and trafficking
Subcellular Localization	the Golgi apparatus, where it plays a role in protein sorting and trafficking
GeneCards	GOLGA8FTLDFET
Human Protein Atlas	GOLGA8FTLDFET
Gene	GOLGA8 (GOLGA8A/GOLGA8B)
Variant	CT dinucleotide repeat expansion in intron
Statistical Strength	p = 5.8 × 10⁻²¹, making this one of the strongest genetic associations for a sporadic neurodegenerative disease[@rosa2026]
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GOLGA8: A New FTLD-FET Gene with Dinucleotide Repeat Expansion

gene · 663 words

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Pathway Diagram

graph TD
    GOLGA8FTLDFET["GOLGA8FTLDFET"]
    neurodegeneration["neurodegeneration"]
    GOLGA8FTLDFET -->|"implicated_in"| neurodegeneration
    style GOLGA8FTLDFET fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning GOLGA8FTLDFET in their description or question text

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