protein

GP45PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GP45PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GP45PROTEIN
Full Name	GCLC (Glutamate-Cysteine Ligase Catalytic Subunit)
Chromosome	1q31
Protein Type	Protein
Function	is a transmembrane protein tyrosine phosphatase critical for lymphocyte function[@biology2020].
Amino Acids	047 aa
UniProt ID	Search UniProt
GeneCards	GP45PROTEIN
Human Protein Atlas	GP45PROTEIN
Immune cells	T cells, B cells, NK cells, macrophages
Brain	Microglia, some neurons, endothelial cells
Isoform patterns	Different isoforms innaive vs. memory T cells
Development	Regulated expression during hematopoiesis[@ptprc2020]
Extracellular domain	Variable due to alternative splicing
Single transmembrane domain	Connects to cytoplasmic portion
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GP45PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GCLC (Glutamate-Cysteine Ligase Catalytic Subunit)

protein · 582 words

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Pathway Diagram

graph TD
    GP45PROTEIN["GP45PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GP45PROTEIN -->|"implicated_in"| neurodegeneration
    style GP45PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GP45PROTEIN in their description or question text

No additional research found