Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR141: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GPR141 (G protein-coupled receptor 141) is an orphan GPCR highly expressed in the brain and peripheral nervous system. It is implicated in neuronal development, neuropathic pain, and potential therapeutic applications.
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| Gene Symbol | GPR141 |
| Full Name | G protein-coupled receptor 141 |
| Chromosome | 7p14.3 |
| Protein Type | Receptor |
| Function | is an orphan G protein-coupled receptor belonging to the Class A rhodopsin family. |
| Primary Expression | Brain, PNS, Sensory Neurons |
| Molecular Weight | 37 kDa |
| Amino Acids | 337 aa |
| Exons | 3 |
| UniProt ID | Q7Z594 |
| NCBI Gene ID | 131034 |
| GeneCards | GPR141 |
| Human Protein Atlas | GPR141 |
| N-terminal extracellular domain | Short, involved in ligand binding for Class A receptors |
| Transmembrane domains | Seven alpha-helices (TM1-TM7) spanning the membrane |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GPR141["GPR141"]
neurodegeneration["neurodegeneration"]
GPR141 -->|"implicated_in"| neurodegeneration
style GPR141 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR141 in their description or question text
No additional research found