gene

GPR173

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GPR173: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GPR173 (SREB3) - Super conserved Receptor Expressed in Brain 3, a GPCR implicated in neurodegeneration

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🧬 Gene Info

Gene Symbol	GPR173
Aliases	SREB3
Function	encodes a 353-amino acid GPCR belonging to the Class A rhodopsin family.
Primary Expression	Brain) family in 2000 by Matsumoto et al
Amino Acids	353 aa
Ensembl ID	ENSG00000146373
GeneCards	GPR173
Human Protein Atlas	GPR173
Transmembrane domains 1-7	Seven alpha-helices spanning the membrane
Extracellular loops	ECL1, ECL2, ECL3 involved in ligand binding
Intracellular loops	ICL1, ICL2, ICL3 coupling to G proteins
C-terminal tail	Contains serine/threonine residues for phosphorylation
Cortex	Highest expression in layers II-III and V, important for cognitive function
Hippocampus	Dense expression in CA1-CA3 pyramidal neurons and dentate gyrus granule cells
Basal ganglia	Moderate expression in striatum and substantia nigra
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GPR173

gene · 1966 words

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Pathway Diagram

graph TD
    GPR173["GPR173"]
    neurodegeneration["neurodegeneration"]
    GPR173 -->|"implicated_in"| neurodegeneration
    style GPR173 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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