Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR37L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GPR37L1 |
| Chromosome | 4q21.3 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain, particularly in oligodendrocytes and astrocytes |
| Molecular Weight | 50 kDa |
| Amino Acids | 462 aa |
| Exons | 4 |
| Ensembl ID | ENSG00000107537 |
| GeneCards | GPR37L1 |
| Human Protein Atlas | GPR37L1 |
| N-terminal Extracellular Domain | Contains multiple glycosylation sites |
| Transmembrane Domains | Seven α-helices (TM1-TM7) spanning the membrane |
| Intracellular Loops | Contain phosphorylation sites for regulation |
| C-terminal Intracellular Domain | Contains PDZ-binding motif |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["GPR37L1"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR37L1 in their description or question text
No additional research found