Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GTF2H1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GTF2H1 |
| Full Name | General Transcription Factor IIH Subunit 1 |
| Chromosome | 11q13.1 |
| Function | GTF2H1 is the largest subunit of the general transcription factor IIH (TFIIH) complex, which is essential for both transcription initiation and nucleotide excision repair (NER). |
| Primary Expression | all brain regions, with high expression in the hippocampus and cerebral cortex |
| Molecular Weight | 62 kDa |
| Amino Acids | 543 aa |
| UniProt ID | P32780 |
| NCBI Gene ID | 2965 |
| Ensembl ID | ENSG00000110768 |
| OMIM | 189903 |
| GeneCards | GTF2H1 |
| Human Protein Atlas | GTF2H1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GTF2H1["GTF2H1"]
neurodegeneration["neurodegeneration"]
GTF2H1 -->|"implicated_in"| neurodegeneration
style GTF2H1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity