gene

GTF2H6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GTF2H6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

General Transcription Factor IIH Subunit 6 - essential for transcription initiation and nucleotide excision repair

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🧬 Gene Info

Gene Symbol	GTF2H6
Full Name	General Transcription Factor IIH Subunit 6
Chromosome	6q25.3
Protein Type	Transcription Factor
Function	is a multiprotein assembly comprising approximately 10 subunits, organized into a core complex and a cyclin-dependent kinase (CDK) module.
Primary Expression	Ubiquitous, high in proliferating cells
Molecular Weight	37 kDa
Amino Acids	327 aa
Exons	10
UniProt ID	[Q86W28](https://www.uniprot.org/uniprot/Q86W28)
Ensembl ID	ENSG00000156802
OMIM	607321
GeneCards	GTF2H6
Human Protein Atlas	GTF2H6
N-terminal domain	Involved in TFIIH core complex interaction
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GTF2H6

gene · 2048 words

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Pathway Diagram

graph TD
    GTF2H6["GTF2H6"]
    neurodegeneration["neurodegeneration"]
    GTF2H6 -->|"implicated_in"| neurodegeneration
    style GTF2H6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GTF2H6 in their description or question text

No additional research found