gene

GUKM1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GUKM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GUKM1 — Guanylate Kinase Associated Protein

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🧬 Gene Info

Gene Symbol	GUKM1
Full Name	Guanylate Kinase Associated Protein
Chromosome	9q34.3
Function	encodes a neuronal protein involved in synaptic function, protein trafficking, and cellular signaling.
Primary Expression	Brain, Spinal cord, Peripheral neurons
NCBI Gene ID	27131
Ensembl ID	ENSG00000106689
GeneCards	GUKM1
Human Protein Atlas	GUKM1
Scaffolding proteins	Associates with PSD-95 and related proteins
Signaling molecules	Interacts with various kinases and phosphatases
Membrane proteins	Links to receptor and channel complexes
LTP formation	Required for activity-dependent synaptic strengthening
LTD induction	Involved in synaptic weakening mechanisms
Structural plasticity	Affects dendritic spine morphology
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GUKM1 — Guanylate Kinase Associated Protein

gene · 539 words

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Pathway Diagram

graph TD
    GUKM1["GUKM1"]
    neurodegeneration["neurodegeneration"]
    GUKM1 -->|"implicated_in"| neurodegeneration
    style GUKM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GUKM1 in their description or question text

No additional research found