Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about H3K9me3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-4a83434d37 | targeted_by | hypothesis | 1.00 |
| h-17dddb7a6a | targeted_by | hypothesis | 1.00 |
| irreversible cell cycle arrest | causes | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-17dddb7a6a | targets | hypothesis | 1.00 |
| h-4a83434d37 | targets | hypothesis | 1.00 |
| Rgfp966 | downregulates | drug | 0.88 |
| RGFP966 | downregulates | drug | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcr | 0.610 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| H3K9me3 Heterochromatin Loss at Pericentromeric Repeats | 0.565 | neurodegeneration | Comparative epigenetic signatures: DNA m |
| NAD+-SIRT1-H3K9me3 restoration enables true senescence rever | 0.380 | alzheimers | Can metabolic interventions truly revers |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620
neurodegeneration | 2026-04-18 | 0 hypotheses
neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-22
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
closed · Rounds: 4 · Score: 1.00 · 2026-04-20
Hypotheses and analyses mentioning H3K9me3 in their description or question text
No additional research found