Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCN1-Mediated Resonance Frequency Stabilization Th: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HCN1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HCN1-Mediated Resonance Frequency Stabilization Therapy | 0.444 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. [PMID:39085604] | Kim ED, Wu X, Lee S, Tibbs GR, Cunningha | Nature | 2024 | 1 |
| The Impact of Altered HCN1 Expression on Brain Function and Its Relationship wit [PMID:37366350] | Zhao K, Li Y, Yang X, Zhou L | Curr Neuropharmacol | 2023 | 1 |
| HCN channels and absence seizures. [PMID:37001612] | Crunelli V, David F, Morais TP, Lorincz | Neurobiol Dis | 2023 | 1 |
| Cardiac and neuronal HCN channelopathies. [PMID:32424620] | Rivolta I, Binda A, Masi A, DiFrancesco | Pflugers Arch | 2020 | 1 |
| HCN1 channels significantly shape retinal photoresponses. [PMID:22183410] | Tanimoto N, Brombas A, Müller F, Seelige | Adv Exp Med Biol | 2012 | 1 |
| HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:41559478] | ["Radaelli C", "Schmitz M", "Liu X", "Sa | Communications biology | 2026 | 0 |
| Comprehensive classification of HCN1 variants linked to neurodevelopmental disor [PMID:41890092] | ["Castelli R", "Marini C", "Porro A", "C | bioRxiv : the preprint server | 2026 | 0 |
| Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-base [PMID:41876451] | ["Levi G", "Sintov A", "Zohar J", "Todde | Translational psychiatry | 2026 | 0 |
| Subthreshold Kir and I [PMID:41689161] | ["Moreno C", "Riquelme D", "Cornejo C", | Biological research | 2026 | 0 |
| Gene expression of the HCN family in rats with pilocarpine-induced epilepsy and [PMID:41903877] | ["Dos Santos R", "Dos Santos M", "da Cos | Brain research | 2026 | 0 |
| Effects of post-stress corticosterone on hippocampal excitability and behavior i [PMID:41654499] | ["Kim C", "Kim J", "Michael S"] | Translational psychiatry | 2026 | 0 |
| Atenolol rescues premature mortality in genetic mouse models of sudden unexpecte [PMID:40991209] | ["Soh M", "Hu A", "Kuanyshbek A", "Moham | Epilepsia | 2026 | 0 |
| Do Subsets of Widefield Vertical Cells Exist in the Mouse Superior Colliculus? [PMID:41846482] | ["Naeem N", "Slusarczyk A", "Bickford M" | The Journal of comparative neu | 2026 | 0 |
| Hyperpolarization-activated cation channels confer tonotopic specialization for [PMID:41822824] | ["Owusu-Nyantakyi K", "Hamlette L", "Ash | bioRxiv : the preprint server | 2025 | 0 |
| HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:40894563] | ["Radaelli C", "Schmitz M", "Liu X", "Sa | bioRxiv : the preprint server | 2025 | 0 |
| Multilayered genetic dissection of autism: insights from whole-exome sequencing, [PMID:41420732] | ["Eser M", "Hekimoglu G", "Kutlubay B"] | Neurogenetics | 2025 | 0 |
| Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid [PMID:40504482] | ["Saini A", "Sharma S", "Rana P", "Khann | Molecular neurobiology | 2025 | 0 |
| Genetic Etiology of Developmental and Epileptic Encephalopathy in a Turkish Coho [PMID:41153369] | ["Sunnetci-Akkoyunlu D", "Kara B", "Ozer | Genes | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Identifying sex similarities and differences in structure and function of the si [PMID:39703520] | Yin Z, Torre E, Marrot M, Peters CH, Fea | Frontiers in medicine | 2024 | 0 |