gene

HEY1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEY1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

Page for HEY1 — Hairy/Enhancer-of-Split Related with YRPW Motif 1

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🧬 Gene Info

Gene Symbol	HEY1
Full Name	Hairy/Enhancer-of-Split Related with YRPW Motif 1
Chromosome	8q21.13
Protein Type	Receptor
Function	is a basic helix-loop-helix-Orange (bHLH-O) transcriptional regulator that functions as a key effector of Notch signaling.
Molecular Weight	33 kDa
Amino Acids	299 aa
Pathways	Notch signaling, notch, Notch, Notch pathway
UniProt ID	[Q9UQV3](https://www.uniprot.org/uniprot/Q9UQV3)
Ensembl ID	ENSG00000164690
OMIM	605253
GeneCards	HEY1
Human Protein Atlas	HEY1
Mesenchymal differentiation	HEY1 promotes osteogenesis, chondrogenesis, and smooth muscle differentiation
Neurogenesis	HEY1 regulates neuronal differentiation, astrogliogenesis, and neural stem cell maintenance
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HEY1 — Hairy/Enhancer-of-Split Related with YRPW Motif 1

gene · 1586 words

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Pathway Diagram

graph TD
    HEY1["HEY1"]
    neurodegeneration["neurodegeneration"]
    HEY1 -->|"implicated_in"| neurodegeneration
    style HEY1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEY1 in their description or question text

No additional research found