gene

HEY2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEY2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

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Summary

Comprehensive information on HEY2 (Hairy/Enhancer-of-Split related with YRPW motif 2), a Notch-signaling transcription factor involved in cardiovascular development and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	HEY2
Full Name	Hairy/Enhancer-of-Split Related with YRPW Motif 2
Chromosome	6q22.31
Protein Type	Transcription Factor
Function	is a basic helix-loop-helix (bHLH) transcription factor that functions as a transcriptional repressor.
Primary Expression	regions involved in learning and memory, and altered HEY2 expression has been implicated in Alzheimer's disease and other neurodegenerative conditions
Molecular Weight	33 kDa
Amino Acids	299 aa
Pathways	Notch signaling
UniProt ID	Q9UBX5
NCBI Gene ID	9489
Ensembl ID	ENSG00000180872
OMIM	604674
GeneCards	HEY2
Human Protein Atlas	HEY2
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HEY2 — AlphaFold Q9UBX5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HEY2 Gene

gene · 1262 words

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Pathway Diagram

graph TD
    HEY2["HEY2"]
    neurodegeneration["neurodegeneration"]
    HEY2 -->|"implicated_in"| neurodegeneration
    style HEY2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEY2 in their description or question text

No additional research found