Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIF1AN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HIF1AN |
| Full Name | Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor |
| Chromosome | 10q24.3 |
| Protein Type | Asparaginyl hydroxylase (2-oxoglutarate-dependent oxygenase) |
| Function | encodes an asparaginyl hydroxylase that negatively regulates hypoxia-inducible factor (HIF) transcriptional activity. |
| Subcellular Localization | patterns. The gene structure is evolutionarily conserved, reflecting the fundamental importance of oxygen sensing in cel |
| Exons | 17 |
| UniProt ID | Q9Y2H8 |
| NCBI Gene ID | 6784 |
| Ensembl ID | ENSG00000141556 |
| OMIM | 607412 |
| GeneCards | HIF1AN |
| Human Protein Atlas | HIF1AN |
| 2001 | Initial identification of FIH-1 enzymatic activity |
| 2003 | Determination of asparagine 803 as the primary hydroxylation site |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HIF1AN["HIF1AN"]
neurodegeneration["neurodegeneration"]
HIF1AN -->|"implicated_in"| neurodegeneration
style HIF1AN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HIF1AN in their description or question text
No additional research found