gene

HLCS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLCS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

HLCS gene encoding holocarboxylase synthetase - biotin-dependent enzyme critical for metabolism and brain function

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🧬 Gene Info

Gene Symbol	HLCS
Full Name	Holocarboxylase Synthetase
Aliases	HLCS gene encoding holocarboxylase synthetase
Chromosome	21q22.12
Protein Type	Enzyme
Function	encodes an essential biotin-dependent enzyme that catalyzes the covalent attachment of biotin to various carboxylases, a process critical for fatty acid synthesis, amino acid catabolism, and glucon...
Subcellular Localization	## Normal Function and Biochemistry
Molecular Weight	81 kDa
Amino Acids	726 aa
UniProt ID	Q9NP80
NCBI Gene ID	3141
Ensembl ID	ENSG00000119669
OMIM	609018
GeneCards	HLCS
Human Protein Atlas	HLCS
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HLCS — AlphaFold Q9NP80 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HLCS Gene

gene · 3082 words

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Pathway Diagram

graph TD
    HLCS["HLCS"]
    neurodegeneration["neurodegeneration"]
    HLCS -->|"implicated_in"| neurodegeneration
    style HLCS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HLCS in their description or question text

No additional research found