Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HMOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | HMOX2 |
| Protein Type | Enzyme |
| Function | HMOX2 (Heme Oxygenase 2) is a constitutively expressed heme oxygenase enzyme that catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO) |
| Amino Acids | 316 aa |
| GeneCards | HMOX2 |
| Human Protein Atlas | HMOX2 |
| N-terminal membrane anchor | A hydrophobic sequence that localizes HMOX2 to the ER membrane |
| Heme oxygenase domain | The catalytic domain that binds and degrades heme |
| C-terminal region | Involved in substrate access and protein interactions |
| Biliverdin | Converted to bilirubin, both acting as antioxidants |
| Iron | Induces ferritin synthesis for safe storage |
| Carbon monoxide | Important signaling molecule |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HMOX2["HMOX2"]
neurodegeneration["neurodegeneration"]
HMOX2 -->|"implicated_in"| neurodegeneration
style HMOX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HMOX2 in their description or question text
No additional research found